Syllabus
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Course Code: BP301T Course Name: Pharmaceutical Organic Chemistry II – Theory |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | • Benzene and its derivatives A. Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s rule B. Reactions of benzene - nitration, sulphonation, halogenation- reactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation. C. Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reaction D. Structure and uses of DDT, Saccharin, BHC and Chloramine |
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| 2 | • Phenols* - Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphthols • Aromatic Amines* - Basicity of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium salts • Aromatic Acids* –Acidity, effect of substituents on acidity and important reactions of benzoic acid. |
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| 3 | • Fats and Oils a. Fatty acids –reactions. b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils. c. Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination. |
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| 4 | • Polynuclear hydrocarbons: a. Synthesis, reactions b. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivatives |
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| 5 | • Cyclo alkanes* Stabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory, Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only | |
