Syllabus
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Course Code: *Program Elective -II MTBT-111 Course Name: Biomaterial Technology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
|---|---|---|
| 1 | Introduction to biomaterials: Definition of biomaterials, History and current status of the field, Types of biomaterials, Important properties of biomaterials. Characterization techniques (X-ray diffraction, UV-VIS, IR and NMR Spectroscopy, Mass spectrometry, HPLC- Size exclusion chromatography). | |
| 2 | Biomaterial degradation in Biological environment; Biodegadable materials: Ceramics and polymers; Processing to improve biocompatibility: sterilization and fixation. Cell interactions with biomaterials: Introduction: Cell-surface interactions and cellular functions. Techniques: Assays to determine effects of cell-material interactions: Cytotoxicity assays, DNA and RNA assays and Protein production assays- Immunostaining. | |
| 3 | Biomaterial implantation and Immune response to biomaterials. Undesired immune responses to biomaterials: innate vs. acquired responses to biomaterials and hypersensitivity reactions. Clinical signs of acute inflammation against biomaterials. In vitro assays for inflammatory response. Biomaterials and thrombosis: Tests for hemocompatability | |
| 4 | Infection, tumorigenesis and calcification of biomaterials. Overview of potential problems with biomaterial implantation, steps to infection, techniques for infection experiments. Biomaterial related tumorigenesis, In vitro and in vivo models for tumorigenesis experiments, pathologic calcification of biomaterials and techniques for pathologic calcification experiments | |
