Syllabus
|
Course Code: **Program Elective -IV MTBT-114 Course Name: Gene Therapy and Gene Editing |
||
| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
|---|---|---|
| 1 | Introduction: Basic concept of gene therapy. Somatic and germ line gene therapy. Gene replacement and gene addition. In vivo, ex vivo and in vitro gene therapy. Transgenic animal models. Vichels for gene transferviral vectors, reterovirus, adenovirus and adenoassociated virus. | |
| 2 | Viral Vectors: Lentivirus, Recombinant SV40 Virus, Non viral vectors, Naked DNA and Transposons., RNADNA chimera, Gene therapies for Crigler Najjar syndrome. | |
| 3 | Gene Therapy and disease: Cystic fibrosis, Duchmne muscular dystrophy, Bleeding disorder, Tryosenemia. Cancer gene therapy | |
| 4 | Genome and Gene Editing: Introduction to Genome and Gene Editing, History of CRISPR, Components of CRISPR/CAS9 system, Editing with homology directed repair, Genome-wide Screening and Regulation of Gene Expression usıng Crispr/Cas9, CRISPR Purification, and Multiplexible Crispr Expression Systems | |
