Syllabus
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Course Code: MTBT-104 Course Name: Medical Biotechnology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Introduction: Classification of genetic diseases: Chromosomal disorders – Chromosomal instability syndromes. Gene controlled diseases – Autosomal and X-linked disorders, Mitochondrial disorders. Molecular basis of human diseases: - Pathogenic mutations Gain of function mutations: Oncogenes, Huntingtons Disease, Pittsburg variant of alpha 1 antitrypsin. Loss of function - Tumour Suppressor. Genomic. Dynamic Mutations - Fragile- X syndrome, Myotonic dystrophy. Mitochondrial diseases | |
| 2 | Gene therapy: Ex-vivo, In vivo, In situ gene therapy, Strategies of gene therapy: gene augmentation Vectors used in gene therapy Biological vectors – retrovirus, adenoviruses, Herpes Synthetic vectors– liposomes, receptor mediated gene transfer. Gene therapy trials – Familial Hypercholesterolemia, ADA, AIDS, Cystic Fibrosis, Solid tumors. Artificial organs and biocompatibility-Overview ,design consideration and evaluation process. | |
| 3 | Recombinant & Immunotherapy; Clinical applications of recombinant technology; Erythropoietin; Insulin analogs and its role in diabetes; Recombinant human growth hormone; Streptokinase and urokinase in thrombosis; Recombinant coagulation factors, Monoclonal antibodies and their role in cancer; Role of recombinant interferons; Immunostimulants; Immunosupressors in organ transplants; Role of cytokine therapy in cancers; Clinical management and Metabolic syndrome: – PKU, Familial Hypercholesterolemia, Rickets, ADA, Congenital hypothyroidism. | |
| 4 | Hazards of biomedical waste-Need for disposal specifically communicable diseases, Disease Epidemiology and mode of transmission of disease. Environment pollution by waste-CAUSES, Consequences, Mitigation and remedies. Treatment-Mechanical and chemical disinfection, Conventional treatments-Incineration, Microwave technology, Autoclave tech, Hydroclave system, Electro thermal reactivation- Pyrolysis/gasification WHO guidelines on management and disposal of biomedical waste from hospitals. | |
