Syllabus
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Course Code: MTBT-102 Course Name: Drug Discovery and Development |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Introduction to Drug Discovery and Development. Lead Optimization and validation strategies. Mechanism of Drug Actions: Inter and intramolecular interactions: Weak interactions in drug molecules; Chirality and drug action; Covalent, ion, ion-dipole, hydrogen bonding, C-H hydrogen bonding, dihydrogen bonding, van der waals interactions and the associated energies. Cation-and OH- interactions. Drug-receptor interactions: Occupancy theory, rate theory, induced fit theory, macromolecular perturbation theory, activation-aggregation theory. Topological and stereochemical consideration. |
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| 2 | Rational Drug Design: Structure activity relationships in drug design, Molecular modeling, Molecular docking and dynamics, Electronic structure methods and quantum chemical methods, De novo drug design techniques and Informatics methods in drug design. Optmization of ADME characteristics and physicochemical properties. Xenobiotic Drug Metabolism. | |
| 3 | Clinical Research- definition and basic concept. Pharmacological Screening and Assays : General principles of screening, correlations between various animal models and human situations. Pharmacological screening models for therapeutic areas. Correlation between in-vitro and in-vivo screens; Special emphasis on cell-based assays, high through put screening, specific use of reference drugs and interpretation of results. Clinical trials and their regulations. | |
| 4 | Concept of Assisted Reproductive Technologies (Artificial Insemination, In VitroFertilziation, Gamete Intrafallopian Transfer and Zygote Intrafallopian Transfer), Gene Therapy- Concept and Applications. Concept of Eugenics. | |
