Syllabus
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Course Code: CHEM403 Course Name: Organic Chemistry-IV |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | NMR Spectroscopy Principle of nuclear magnetic resonance, the PMR spectrum,number of signals, peak areas, , magnetic equivalent and nonequivalent protons, positions of signals and chemical shift, shielding and deshielding of protons, proton counting, splitting of signals and coupling constant. Discussion of PMR spectra of the molecules: ethyl bromide, n-propyl bromide, isopropyl bromide, 1,1- dibromoethane, ethanol, acetaldehyde, ethyl acetate, toluene, benzaldehyde and acetophenone. Organometallic Compounds Grignard reagents: formation, structure and chemical reactions. Organozinc compounds: formation and chemical reactions. Organolithium compounds: formation and chemical reactions. Reactions of Grignard and organolithium reagents with epoxides. |
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| 2 | Carbohydrates Classification and nomenclature of Monosaccharides, mechanism of osazone formation, interconversion of glucose, fructose and mannose, chain lengthening and chain shortening of aldoses. Configuration of monosaccharides. Determination of ring size of glucose and fructose. Open chain and cyclic structure of D(+)-glucose & D(-) fructose. Mechanism of mutarotation. An introduction to disaccharides (maltose, sucrose and lactose; reducing and non-reducing) and polysaccharides (starch and cellulose) without involving structure determination. Amino Acids and Peptides sequencing Classification α-of amino acids. Acid-base behavior, isoelectric point, Preparation (Gabriel phlamide, Erlenmeyer azlactone, Strecker method) and properties of α-amino acids(ester of –COOH group, acetylation of –NH2 group, complexation with Cu2+ ions, ninhydrin test, Hydantoin formation), Structure and nomenclature of peptides, Peptide structure determination, end group analysis (DNFB, Edman thiohydantoin and carboxypeptidase method), selective hydrolysis of peptides. Introduction to Heterocyclic Compounds Molecular orbital picture and aromatic characteristics of pyrrole, furan, thiophene and pyridine. Comparison of basicity of pyridine, piperidine and pyrrole. |
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