Syllabus
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Course Code: B-BTY -605 Course Name: Immunology-II |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Antigen–antibody interactions: Antibody affinity, antibody avidity, Agglutination &
Precipitation reactions; Immunodiffusion; Radio immunoassay & ELISA. Complement system: Components if complement system,Complement activation by classical, alternate and MB lactin pathways, Biological consequences of complement activation and regulation. Major Histocompatibility Complex (MHC): General organization and inheritance of MHC, Structure, distribution and role of class I & II MHC molecules;. Antigen Processing & Presentation: A brief account of antigen processing and presentation pathways. |
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| 2 | Biology of the T lymphocyte: Structure and role of T cell receptor, and co-receptor,
T cell development, generation of receptor diversity, selection and differentiation. Cell mediated cytotoxic responses: General properties of effector T cells, cytotoxic T cells (Tc), natural killer cells; NKT cells and antibody dependent cellular cytotoxicity (ADCC). Tolerance, autoimmunity and hypersensitivity: Central tolerance, pherpheral tolerance, autoimmunity, autoimmune diseases, possible mechanisms of induction of autoimmunity, Hypersensitivity reactions: Gell and Coombs classification, IgE mediated (Type I) hypersensitivity, antibody mediated cytotoxic (Type II) hypersensitivity, immune complex mediated (type III) hypersensitivity and delayed type (Type IV) hypersensitivity. Transplantation immunology and vaccines : Immunological basis of graft rejection, clinical manifestations, Vaccines - active and passive immunization |
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