Syllabus
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Course Code: B-BCH-301 Course Name: Metabolism-I |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Bioenergetics: Concept of free energy, standard free energy, relation between equilibrium
constant and standard free energy change and coupled reactions. Biological oxidationreduction: redox potentials, relation between standard reduction potentials and free energy
change (derivations and numericals included). High-energy compounds: phosphate group
transfer potential, free energy of hydrolysis of ATP, PEP and other sugar phosphates along with
reasons for high G. Carbohydrate Metabolism: Reactions and energetics of glycolysis. Alcoholic and lactic acid fermentations. Feeder pathways, Entry of fructose, galactose, mannose etc into glycolysis. Reactions and energetics of TCA cycle. Regulation of glycolysis and TCA cycle. Gluconeogenesis. |
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| 2 | Carbohydrate-related other metabolic pathways: Glycogenesis and glycogenolysis.
Regulation of glycogen metabolism. Reactions and physiological significance of pentose
phosphate pathway. Glyoxylate cycle. Electron Transport Chain and Oxidative Phosphorylation: Structure of mitochondria, organization and sequence of electron carriers, sites of ATP production, inhibitors of electron transport chain. Oxidative phosphorylation: chemiosmotic theory, structure of ATP synthase, binding change mechanism for proton driven ATP sysnthesis, Inhibitors and uncouplers of oxidative phosphorylation. Transport of reducing equivalents from cytosol into mitochondria. |
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