Syllabus
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Course Code: B-BTY -505 Course Name: Medical Biotechnology-II |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Clinical management and Metabolic manipulation - PKU, Familial
Hypercholesterolemia, Rickets, ADA, Congenital hypothyroidism; Gene therapy Exvivo, Invivo, Insitu gene therapy Stratagies of gene therapy: gene augmentation –
ADA defeiciency, CFTR Prodrug therapy/ suicide gene – glioma, evoking immune response – melanoma TFO, Antisense therapy, Ribozymes, Protein Aptamers,
Intrabodies Vectors used in gene therapy- Biological vectors – retrovirus, adenoviruses, Herpes Synthetic vectors– liposomes, receptor mediated gene transfer; Gene therapy trials – Familial Hypercholesterolemia, Cystic Fibrosis, Solidtumours. Cell and tissue engineering: Encapsulation technology and therapeutics - Diabetes, Hypothyroidism, Haemophilia, Bioartificial organs, Artificial Cells- ForHaemophilia, Phenylkeptonuria, Diabetes |
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| 2 | Nanomedicine - Nanoparticles, Nanodevices-medical microrobotics,
nanoroboticsMicrobiovers, Nanomedicine and Nanosurgery – for cancers,
neurological disorders. Functional cloning – anti-haemophilic factor; Positional cloning- Dystrophin; Gene products in medicine - Humulin, Erythropoietin, Growth Hormone/Somatostatin, tPA, Interferon; DNA based vaccines ,subunit vaccines – Herpes Simplex Virus; Attenuated Vaccines– Cholera; Vector vaccines – Cholera and Salmonella |
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