Syllabus
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Course Code: IN-BTY -703 Course Name: Bioprocess and fermentation Technology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Introduction to bioprocess technology.Range of bioprocess technology and its chronological development.Basic principle components of fermentation technology.Types of microbial culture, Isolation and screening of microbes of industrial importance, Strain improvement: mutation and genetic manipulations Culture preservation techniques and its growth kinetics– Primary and Secondary metabolites, Feedback inhibition & repression, Batch, Fedbatch and Continuous culture. Design of bioprocess vessels- Significance of Impeller, Baffles, Sparger; Types of culture/production vessels- Airlift; Cyclone Column; Packed Tower and their application in production processes.Principles of upstream processing – Media preparation, Inocula development and sterilization. |
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| 2 | Introduction to oxygen requirement in bioprocess Energetics of microbial growth in fermenters: Reaction rates, heat and mass transfer, transport phenomenon in reactors, macrscopic balances of energy and energy flow etc Introduction to Upstream and downstream processing of industrial fermentations, Cell disruptions, Flocculation, Filterations, Ultrafilteration, ultracentrifugation, gel filtration, chromatographic methods, two phase aqueous separations. Cells andenzyme immobilizations Fermentation of :Antibiotics (Penicillin, Streptomycin), Organic acids (Citric acid, Lactic acid), Enzymes (Penicillin G Acylase, Streptokinase), ethanol, Recombinant Proteins (Insulin).Hygiene and safety in fermentation laboratory |
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