Syllabus
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Course Code: IN-BTY-605 Course Name: Immunology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Introduction to immune system: Memory, specificity, diversity, innate and acquired immunity, self vs non-self-discrimination, structure and functions of primary and secondary lymphoid organs
Cells involved in immune responses: Phagocytic cells and their killing mechanisms; T and B lymphocytes, differentiation of stem cells and idiotypic variations Nature of antigen and antibody: Antigens vsimmunogen, haptens, structure and functions of immunoglobulins; isotypic, allotypic and idiotypic variations Humoral and cell mediated immune responses: kinetics of primary and secondary immune responses, complement activation and its biological consequences, antigen processing and presentation, cytokines and costimulatory molecules- role in immune responses, T and B cell interactions. Major Histocompatibility Complex (MHC) genes and products: polymorphism of MHC genes, role of MHC antigens in immune responses, MHC antigens in transplantation |
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| 2 | Generation of diversity in immune system: Clonal selection theory- concept of antigen specific receptor, organization and expression of immunoglobulin genes- generation of antibody diversity, T-cell receptor diversity. Measurement of antigen –antibody interaction: Production of polyclonal and monoclonal antibodies- principles, techniques and applications; Agglutination and precipitation techniques; Radio immunoassay; ELISA; Immunofluorescence assays- Fluorescence activated cell sorter (FACS) technique. Immunization: Active & passive immunization, vaccines and their types, role of vaccines in the prevention of diseases Tolerance vs activation of immune system: Immune tolerance, immunosuppression, hypersensitivity (Types I, II, III and IV). Immune responses in diseases: Immune responses to infectious diseases- viral, bacterial and protozonal; cancer and immune system, immunodeficiency disorders and autoimmunity |
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