Syllabus
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Course Code: IN-BTY-301 Course Name: Metabolism |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Bioenergetics: Concept of free energy, standard free energy, relation between equilibrium constant and standard free energy change and coupled reactions. Biological oxidation-reduction: redox potentials, relation between standard reduction potentials and free energy change (numericals included). High-energy compounds: phosphate group transfer potential, free energy of hydrolysis of ATP, PEP and glucose-6 phosphate along with reasons for high ∆G. Carbohydrate Metabolism: Reactions and energetics of glycolysis. Alcoholic and lactic acid fermentations.Feeder pathways, Entry of fructose into glycolysis.Reactions and energetics of TCA cycle.Regulation of glycolysis and TCA cycle.Gluconeogenesis.Glycogenesis and glycogenolysis.Reactions and physiological significance of pentose phosphate pathway. Electron Transport Chain and Oxidative Phosphorylation: Structure of mitochondria, organization and sequence of electron carriers, sites of ATP production, inhibitors of electron transport chain. Oxidative phosphorylation: chemiosmotic theory, structure of ATP synthase, Inhibitors and uncouplers of oxidative phosphorylation. Transport of reducing equivalents from cytosol into mitochondria. |
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| 2 | Lipid Metabolism: Introduction, hydrolysis of triacylglycerols, activation of fatty acids, transport of fatty acyl CoA into mitochondria, beta-oxidation of saturated, and odd chain fatty acidss. ATP yield from fatty acid oxidation. Biosynthesis of saturated fatty acids.triglycerides.Metabolism of ketone bodies. Amino acid Metabolism: General reactions of amino acid metabolism: transamination, oxidative and non-oxidative deamination and decarboxylation. Urea cycle.Glycogenic and ketogenic amino acids.Biosynthesis of aromatic amino acids.Glucose-Alanine cycle. Nucleotide Metabolism: Sources of the atoms in the purine and pyrimidine molecules, denovo biosynthesis and degradation of purine and pyrimidine nucleotides, Regulation of purine and pyrimidine biosynthesis. Salvage pathways of purines and pyrimidines. |
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