Syllabus
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Course Code: IN-BTY-203 Course Name: Genetics |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Genetics - Definition, history and scope Mendelism & Chromosome Theory: Mendel’s principles, applications of Mendel’s principles,Chromosome Theory of Heredity (Sutton-Boveri), Inheritance patterns, phenomenon of Dominance, Inheritance patterns in Human (Sex-linked, Autosomal, Mitochondrial, Unifactorial , Multi-factorial). Deviation from Mendel’s Dihybrid phenotype, Linkage, Sutton’s view on linkage, Morgan’s view on linkage, Bateson & Punnet’s Coupling & Repulsion hypothesis. Linkage & Crossing over: Chromosome theory of Linkage, kinds of linkage, linkage groups, types of Crossing over, mechanism of Meiotic Crossing over, kinds of Crossing over, theories about the mechanism of Crossing over, cytological detection of Crossing over, significance of Crossing over. Allelic Variation & Gene function – Multiple allele, Genetic interaction, Epiststic interactions, Non-Epistatic inter-allelic genetic interactions, Atavism/Reversion, Penetrance (complete & incomplete), Expressivity, Pleiotropism, Modifier/Modifying genes. Non-Mendelian inheritance – Evidences for Cytoplasmic factors, cytoplasmic inheritance, extranuclear inheritance (mitochondrial, chloroplast) |
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| 2 | Chromosomal variation in Number & Structure – Euploidy, Non-disjunction &Aneuploidy,Aneuploid segregation in plants, Polyploidy in Plants & Animals, Induced Polyploidy, applications of Polyploidy, Chromosomal Mosaics, Giant chromosome, Deletion, Duplication, Inversion, Translocation, Position Effect, Centromeric& Non-centromeric breaks in chromosomes, chromosomal rearrangements in Human being, Chromosomal aberrations & evolution. Gene Mutation Chromosome Mapping - Haploid mapping (2 point & 3 point cross), Diploid mapping (Tetrad analysis), determination of linkage groups, determination of map distance, determination of gene order, cytological mapping. Human Cyto-Genetics – Human karyotype, Banding techniques, classification, use of Human Cyto-genetics in Medical science, Chromosomal abnormalities in spontaneous abortions, viable monosomies&trisomies, chromosomal deletions & duplications, genetics of chromosomal inversions & translocations, human traits, Genomic position effects on Gene expression, Inborn diseases Pedigree analysis – Symbols of Pedigree, Pedigrees of Sex-linked & Autosomal (dominant & recessive), Mitochondrial, Incomplete dominance & Penetrance. |
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