Syllabus
|
Course Code: CHEM 403 Course Name: Organic Chemistry Special-V |
||
| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
|---|---|---|
| 1 | Enzymes Introduction and historical perspective, chemical and biological catalysis, remarkable properties of enzymes like catalytic power, specificity and regulation. Nomenclature and classification, extraction and purification. Fischer's lock and key and Koshland's induced fit hypothesis, concept and identification of active site by the use of inhibitors, affinity labeling. Enzyme kinetics, Michaelis-Menten and Lineweaver-Burk plots, reversible and irreversible inhibition. Mechanism of Enzyme Action Transition-state theory, orientation and steric effect, acid-base catalysis, covalent catalysis, strain or distortion |
|
| 2 | Mechanism of action of chymotrypsin, papain and carboxypeptidase A. Co-enzyme Chemistry Cofactors as derived from vitamins, coenzymes, prosthetic groups, apoenzymes. Structure and biological functions of coenzyme A, thiamine pyrophosphate (TPP), pyridoxal phosphate (PLP), NAD+, NADP+, FMN, FAD. Mechanisms of reactions catalyzed by the above cofactors. Prostaglandins: General Introduction, nomenclature and biological roles of prostaglandins. Synthesis of PGE2 and PGF2β. |
|
| 3 | Terpenoids General aspects of structure determination of terpenoids. Structure elucidation and synthesis of Geraniol, β-terpineol, β-pinene, camphor, farnesol and squalene. Biogenetic isoprene rule and biogenesis of terpenoids. |
|
| 4 | Steroids Isolation and nomenclature of steroids. Structure elucidation, synthesis (Woodward) and stereochemistry of cholesterol. Methods for the following conversions. i) Cholesterol -> Testosterone ii) Cholesterol -> Progesterone iii) Cholesterol -> 5 - α and 5 - β cholanic acids. Johnson's hydrochrysene approach towards the synthesis of Androsterone. |
|
