KUK - LMS

Syllabus

MODULE NO / UNIT	COURSE SYLLABUS CONTENTS OF MODULE	NOTES
Course Code: CHEM 401 Course Name: Organic Chemistry Special-III
1	Disconnection Approach-I An introduction of synthons and synthetic equivalents, general principles of the disconnection approach, functional group interconversions, the importance of order of events in organic synthesis, one group C-X and two group C-X disconnections, one group C-C disconnection, chemoselectivity, regioselectivity, regiospecificity, stereoselectivity and stereospecificity.
2	Disconnection Approach-II Reversal of polarity, amine synthesis, use of Wittig reagents, use of acetylene and aliphatic nitro compounds in organic synthesis, synthesis of three membered rings, photochemistry in organic synthesis-synthesis of four membered rings, uses of ketenes in organic synthesis, synthesis of five and six membered rings.
3	Disconnection Approach-III Principle of protection of alcoholic, amino, carbonyl and carboxylic groups, Two group C-C disconnection- Diels Alder reactions, 1,3-difunctionalized compounds and α,β-unsaturated carbonyl compounds, control in carbonyl condensations, 1,5-difunctionalized compounds-Michael addition and Robinson Annelation.
4	Application of Disconnection A brief survey of various approaches used towards the synthesis of Juvabione and their relative merits and demerits, Sarette's stereospecific synthesis of Cortisone. Principle of Green chemistry and its applications Basic Principle and need of green chemistry, Different tools for green synthesis (Elementary idea of green reagent, green solvent, green catalyst, solid phase, mw and ultrasound assisted) atom economy, synthesis involving basic principle of green chemistry-synthesis of adipic acid and BHC synthesis of Ibuprofen.
5	Aromaticity Concept of aromaticity, non-aromaticity, anti-aromaticity, homoaromaticity, and psuedo-aromaticity. Aromaticity in charged rings, HMO and PMO for determining aromatic, non-aromatic and anti-aromatic character of annulenes having various $pi;-electron systems, application of 1H-NMR in determining aromatic character of annulenes.