Syllabus
|
Course Code: CHEM 404 Course Name: Pharmaceutical Chemistry Special-VI |
||
| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
|---|---|---|
| 1 | Heat Transfer: Introduction, modes of heat transfer, Fourier's law of heat flow, thermal conductivity, steady state conduction. Equipments: Finned tube (extended surface) heat exchanger, plate heat exchanger, spiral heat exchanger, scraped heat exchanger and air cooled heat exchanger. Distillation: Introduction, vapour – liquid equilibrium, partial vaporization, partial condensation, volatility, relative volatility, methods of distillation for two component systems–fractional distillation, azeotropic distillation, steam distillation, extractive distillation. Filtration: Introduction, classification of filters, plate & frame filter presses, candle filter, filter media, filter aids, washing of filter cakes, filtration theory – constant pressure filtration, constant rate filtration, filtration cycle, centrifuges, batch top driven centrifuge, batch under driven centrifuge, disk type centrifuge. |
|
| 2 | Drying: Introduction, rate of drying, constant rate period, critical moisture content, falling rate period, equilibrium moisture, free moisture, bound and unbound moisture, drying equipments – tray dryers, drum dryers, rotary dryers, spray dryers, flash dryers. Crystallization: Introduction, supersaturation, modes of generation of supersaturation, nucleation, primary nucleation, secondary nucleation, crystal growth, △ L law of cyrstal growth, growth rate and growth coefficients, crystallisation equipments – Tank crystallizers, circulating magma – vacuum crystallizers, circulating liquid evaporator crystallizers. Fluid Flow: Introduction, Newtonian and non-Newtonian fluids, viscosity, effect of temeprature on viscosity, kinematic viscosity, laminar and turbulent flows, Reynolds number, Bernoullis equation without friction, orificemeter, venturimeter, pumps, types of pumps. |
|
| 3 | Reactors: Introduction to reactor design, ideal batch reactor, space time, space velocity, steady state mixed flow reactor, steady state plug flow reactor.
Chemical process development: Process design development, types of design process development, plant location, plant layout, plant operation and control, material handling. Safety and loss prevention: Health and safety hazards, source of exposure, exposure evaluation, exposure hazard control, fire and explosion hazard, safety regulation, loss prevention. |
|
| 4 | Chromatographic techniques: Principles of separation, applications and recent trends in chromatography: Column, Paper, Thin layer and gas chromatography, HPLC, HPTLC, Size exclusion chromatography, Affinity chromatography, Ion-exchange chromatography. Biological Standardization: Bioassay and Radioimmunoassay: ELISA, radioimmunoassay of drugs like Digitalis & insulin. |
|
