Syllabus
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Course Code: CHEM 401 Course Name: Pharmaceutical Chemistry Special-III |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Mechanistic and biosynthetic approach to plant secondary metabolites:
Acetate-malonate pathway: Biosynthesis of plant fatty acids, biosynthesis and oxidation of ricinoleic acid). Polyketides: Biosynthesis of 6-methylsalicyclic acid, pencillic acid, griseofulvin. Acetate- mevalonate pathway: Biosynthesis of psoralen, gibberellic acid, cholesterol, conessine. Shikimic-acid pathway: Biosynthesis of chlorogenic acid and cichoriin, Cyanin, Quercetin, Biosynthesis of Porphyrins. |
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| 2 | Alkaloids:
Structure, synthesis, biosynthesis and biological importance of the following: Ephedrine, (+)-Coniine, Nicotine, Quinine and Reserpine. Carotenoids; Structure, synthesis and biogenesis of β-carotene and Vitamin-A. |
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| 3 | Carbohydrates: Introduction, stereoisomerism, mutarotation of monosaccharides, ring structure of glucose, structure elucidation, of disaccharides, sucrose, maltose, lactose, polysaccharides, starch, glycosides, general structure elucidation. Terpene: General introduction, isoprene rule, isolation of terpenes, General methods of structure determination of terpenes, structure elucidation of citral, menthol and camphor. |
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| 4 | Steroids: Isolation, nomenclature, structural elucidation with special reference to Cholesterol, ergosterol and cardiac glycosides Methods for the following conversions: i) Cholesterol ->Testosterone ii) Cholesterol -> Progesterone Porphyrins Structures elucidation of chlorophyll, General structural features of haemoglobin (not structure elucidation). |
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