Syllabus
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Course Code: CHEM 304 Course Name: Pharmaceutical Chemistry Special-I |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Synthon approach-I Definition of terms- Disconnection, synthons, functional group interconversions (FGI), synthetic equivalents. General principles of the disconnection approach, the importance of order of events in organic synthesis, one group C-X and two group C-X, One group C-C disconnections-alcohols and carbonyl compounds, chemoselectivity, reversal of polarity, amine synthesis. |
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| 2 | Synthon approach-II Two group C-C disconnections-1, 3 & 1,5-difunctionalized compounds, Stereochemistry in organic synthesis-stereoselectivity, stereospecificity, regioselectivity and regiospecificity. Synthon approach in the synthesis of the following drugs: Salbutamol, Propanolol, moxnidazole, nafimidone, drildone, belfosih. Ocfentanil, afornine Principle of protection of alcoholic, amino, carbonyl and carboxylic groups. |
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| 3 | Heterocyclic Compounds - I Systematic (Hantzsch-Widman) nomenclature for monocylic and fused ring systems. Methods of synthesis and Reactions including mechanism of the following five-membered 1,2- and 1,3-heterocycles: pyrazole, imidazole, oxazole, isooxazole, thiazole, isothiazole; their basic character. |
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| 4 | Heterocyclic Compounds - II Methods of synthesis and Reactions including mechanism of the following six-membered heterocycles: purines and pyrimidines. Caffeine, xanthine, theobromine, theophylline. Methods of synthesis and Reactions including mechanism of-Indoles, quinolines and isoquinolines. Flavanoids: Occurrence, nomenclature and general methods of structure determination, isolation, importance and synthesis of Cyanin, Quercetin, Diadzein and Chrysin. |
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