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Kurukshetra University, Kurukshetra

Syllabus

Course Code: CHEM 306    Course Name: Organic Chemistry Special Practical-I

MODULE NO / UNIT COURSE SYLLABUS CONTENTS OF MODULE NOTES
1 Preparations of Organic compounds involving two and three stages:
Typical preparations from which the two and three stage preparations can be chosen are:
1. Toluene — p-nitrotoluene — p-nitrobenzoic acid — p-amino benzoic acid
2. Hydroquinone — Benzoquinone — 5- Hydroxy benzoxathiole-2-one —5-Acetoxy benzoxathiol-2-one
3. Benzene — Acetopheneone — Acetophenone oxime — Acetanilide
4. Benzaldehyde — Benzoin — Benzil — Benzillic acid
5. Acetylacetone — 4,6-dimethylpyridine-2-mercaptopyrimidine — 4,6-dimethyl-2- hydrazinpyrimidine — 1-(4'-6'-dimethylpyridine-2'yl) 3,5-dimethylpyrazole
6. Nitrobenzene — m-dinitrobenzene — m-nitroaniline — m-nitrophenol
7. Phthalic acid — phthalic anhydride – phthalimide — Anthranilic acid
8. Acetophenone — Benzalacetophenone — epoxide
9. Cyclohexanone —Cyclohexanone oxime—caprolactam
10. Phthalic anhydride—o-benzolylbenzoic acid—anthraquinone.
11. O-Cholobenzoinc acid —N-phenylanthranilic acid —acridone.
12. Cholrobenzene—2,4-dinitrochlorobenzene —2,4-dinitrophenol
13. Bromobenzene—triphenylcarbinol-tritylchloride
14. Resorcinol—resacetophenone — 4-ethyl resorcinol
15. Resorcinol — 4-methyl-7-hydroxycoumarin — 6 and 8- nitro-4-methyl-7-hydroxycoumarin
16. Phenol — salicylaldehyde —coumarin
17. Aniline — 2,4,6-tribromaniline — 1,3,5-tribromobenzene
18. Resorcinol—resacetophenone — Chalcone
19. Any other multi step reaction as per requirement
All the students must check the progress of reaction and purity of Final products for all the stages of preparation by Thin layer Chromatography.
2 Demonstration of different software useful in Chemistry for drawing the structure of Organic compounds as well as for the computational studies of small organic molecules.
Draw the Scheme used for a multi step preparation (two or three) using any structural drawing tool & get the IUPAC name and predicted 1H-NMR spectrum for each compound involved in multi step preparation.
Brief idea of given terms: Molecular graphics, Molecular minimization, Molecular Docking, Pharmacophore, QSAR, Optimization, Single point energy and Spectral analysis.
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