Syllabus
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Course Code: FND-102 Course Name: Advanced Nutritional Biochemistry-I |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | 1. PRINCIPALS OF BIOENERGETICS- Concept of free energy, Oxidation and reduction, concept of cell, high energy compounds (ATP, PEP, and Phosphogens), role of ATP/ADP cycle in transfer of high energy phosphates, concept of coupled reactions, equilibrium & non- equilibrium reactions, committed steps, caloric homeostasis & futile cycles. 2. CARBOHYDRATES- Definition, classification. Monosaccharides: Classification, occurrence, structure, stereoisomerism (DL and RS systems),optical isomerism and chemical reactions of the functional groups, derivatives of monosaccharides- deoxy sugars and amino sugars. Disaccharidesof nutritional importance (sucrose, maltose, lactose), Polysaccharides-Homopolysaccharides- starch, glycogen, cellulose, Heteropolysaccharides- glycoprotein, proteoglycans, mucopolysaccharides, pectins. |
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| 2 | 3. LIPIDS- Definition, classification. Structure, properties and functions of fatty acids (including essential fatty acids) Trans fatty acids, prostaglandins,acylglycerols, phospholipids, sphingolipids, glycolipids, steroids (including role of cholesterol). Chemical composition and biological role of lipoproteins, Characterization of fats- saponification, iodine, acid, acetyl and peroxide value. 4. AMINO ACIDS AND PROTEINS- Common structural features, classification based on the nature of R group, non-protein amino acids, essential amino acids and titration curves of monoamino-monocarboxilic, monoamino-dicarboxilic and diamino-monocarboxilic acids. Peptide bond, biological role of proteins, classification of proteins, levels of protein structure- primary, secondary (super secondary elements in brief), tertiary and quaternary structure, forces stabilizing protein structure, denaturation of proteins. | |
| 3 | 5. ENZYMOLOZY- General Characteristics, classification and nomenclature, coenzyme, cofactor, prosthetic group, concept of holoenzyme and apoenzyme, units of enzyme activity, Multienzyme systems and multifunctional enzymes with specific examples and significance,Enzyme kinetics- Michaelis-Menten and Lineweaver-Burk equation for monosubstrate reactions, Km, kcat (turnover number), bisubstrate reactions. 6. MECHANISM OF ACTION OF HORMONES-Classes of hormones, signal transduction and intracellular messengers, chemistry and functions of thyroid, parathyroid, adrenal, pancreatic, gastric and reproductive hormones; hypothalamus and pituitary, hormone replacement therapy |
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| 4 | 7. NUCLEIC ACIDS- Nitrogenous bases, experimental proof of DNA and RNA as genetic material, Chargaff’s rules, double helical model of DNA (A, B and Z), DNA packaging, types of RNA and their functions. 8. Nutrigenomics and Nutraceuticals. |
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