Syllabus
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Course Code: BT-304 Course Name: Immunology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Introduction and overview: Introduction and overview of immunology, cells of immune system, innate and cellular immunity, physical and chemical barriers, cellular defences, inflammation, receptors involved in innate immune system, cells and organs involved in adaptive immune response, fate of antigen after penetration, interrelationship between innate and acquired immunity. | |
| 2 | Antigens, antibodies and their interactions: Requirements of immunogenicity, primary and secondary responses, major classes of antigens, basic structure of antibodies, antibody classes and biological activity, antigenic determinants on immunoglobulins, immunoglobulin super family, organization and expression of immunoglobulin genes, antigen-antibody interactions: immunoprecipitation, agglutination, ELISA, immunofluorescence, flow cytometry | |
| 3 | Generation of B-cell and T-cell responses: Complement system and its activation, Structure and role of Major Histocompatibility Complex, T-cell receptor- structure, complex and accessory membrane molecules, thymic selection of T-cells, T-cell activation and differentiation, B-cell maturation, activation and proliferation, humoral response, Cytokines- properties and receptors. | |
| 4 | Immune system in health and disease: Hypersensitivity reactions-their types and mechanism, Cancer and the immune system, Cancer immunotherapy, Hybridoma technology: commercial production of antibodies using monoclonal antibodies. Vaccines: live attenuated, killed, subunit, conjugate and DNA vaccines. Production of recombinant antibodies and edible vaccines, development of diagnostics using biotech and nanotech tools. | |
