Syllabus
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Course Code: BT-204 Course Name: Bioinformatics |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Bioinformatics and Biological Databases: Central Dogma of molecular biology. Basics of Human Genome project. Introduction, Goal, Scope, Applications of Bioinformatics. Introduction to Biological Databases and Information Retrieval systems. Introduction to Pairwise Sequence Alignment: Evolutionary Basis, Sequence Homology versus Sequence Similarity, Sequence Similarity versus Sequence Identity, scoring matrix. Database Similarity Searching: Exhaustive and Heuristic, Basic Local Alignment Search Tool (BLAST), FASTA. Multiple Sequence Alignment: Exhaustive Algorithms, Heuristic Algorithms. Position- Specific Scoring Matrices, Motifs and Domains, Regular Expressions, Protein Family Databases, Sequence Logos | |
| 2 | Gene and Promoter Prediction: Categories of Gene Prediction Programs, Gene Prediction in Prokaryotes, Gene Prediction in Eukaryotes, Promoter and Regulatory Elements in Prokaryotes, Promoter and Regulatory Elements in Eukaryotes, Prediction Algorithms. Molecular Phylogenetics: Molecular Evolution and Molecular Phylogenetics, Terminology, Gene Phylogeny versus Species Phylogeny, Forms of Tree Representation, Finding a True Tree. Distance-Based Methods, Character-Based Methods, Phylogenetic Tree Evaluation, Phylogenetic Programs. |
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| 3 | Structural Bioinformatics: Introduction to Protein Structure Database. Protein Structural Visualization, Protein Structure Comparison, Protein Structure Classification. Methods of Secondary and tertiary Structure Prediction for Globular Proteins: Homology Modelling, Threading and Fold Recognition, Ab Initio Protein Structural predictions. Introduction to Drug Discovery. | |
| 4 | Genomics and Proteomics: Genome Mapping, Genome Sequence Assembly, Genome Annotation, Comparative Genomics, Functional Genomics, Sequence-Based Approaches, Microarray-Based Approaches, Comparison of SAGE and DNA Microarrays, Introduction to Proteomics, various tools and techniques, application/significance of Proteomics to mankind. | |
