Syllabus
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Course Code: MMB-103 Course Name: Immunology & Virology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Immunity: Innate immunity, factors affecting innate immunity. Acquired immunity- natural and artificial immunity, active and passive immunity. Antigen, hapten and adjuvants. Immunoglobulins: types, structure and functions. Molecular mechanisms responsible for generating diversity of antibodies and T cell receptors. Hybridoma technology and monoclonal antibodies, and its applications. Lymphoid organs and cells of immune system. |
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| 2 | Immune response: Cellular and humoral immune response. Brief account of Complement system and Major histocompatibility complex. Mechanisms of autoimmunity; Immune checkpoints, Autoimmune components of diabetes mellitus (DM), multiple sclerosis (MS), pernicious anemia; Infections leading to autoimmune diseases. Immunodeficiency diseases. Tumor antigens, immune response to tumors and immunotherapy of tumors. |
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| 3 | Classification, Properties of viruses, Morphology and Structure of viruses- Capsid and its symmetry with special reference to bacteriophage, Lytic and lysogenic cycle. Viroids and Prions, Virus genome types. Double stranded DNA (dsDNA). Gapped DNA genomes. Single-stranded (ssDNA) genomes. Double stranded RNA (dsRNA). Single stranded RNA (ssRNA): (+) strand RNA. Single stranded (+) sense RNA with DNA intermediate. Single stranded RNA (-) sense. Principal events involved in replication: Adsorption, penetration, uncoating nucleic acid and protein synthesis, intracellular trafficking, assembly, maturation and release, viral-host interaction, Host response to viral infection. |
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| 4 | Virus growth: Primary cell, Diploid cell strains, Continuous cell lines. One step growth curve, Detection of virus growth in cell culture. Techniques for visualization and enumeration of viral particles, assays for virus estimation. Vaccines & Anti-Viral drugs: Herd Immunity. Requirement of an effective vaccine. Different ways of making vaccine. Inactivated vaccine. Subunit vaccines. Subunit vaccines. Live attenuated vaccines. Polio eradication. Anti-Viral drugs. Search for antiviral drugs. The path for drug discovery. Mechanism based screens. Cell based screen. Antiviral screening. Resistance to antiviral drugs. |
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