Syllabus
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Course Code: BCH-404B Course Name: Genetics & Evolution |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Inheritance: Mendelian principles; extensions of Mendelian principles (codominance, incomplete dominance, gene interactions, pleiotropy, genomic imprinting, penetrance, expressivity and phenocopy); cytoplasmic inheritance; concept of gene; allele (multiple and pseudo); linkage; sex linked inheritance, mutations and recombination. | |
| 2 | Human Genetics: Human karyotype: banding and nomenclature of banding and aberrant karyotypes; Common syndromes due to numerical chromosome changes (triploidy, trisomy, monosomy) and structural alterations (translocation, duplications, deletions and fragile sites); Linkage map and Pedigree analysis; Identification of human genetic diseases- positional cloning illustrated using examples- Duchenne muscular dystrophy, cystic fibrosis, Huntington’s disease. | |
| 3 | Evolutionary Thoughts and History: Lamarckism and Darwinism; Adaption, Struggle, Fitness and natural selection; The evolutionary synthesis; The evolutionary time scales; Eras, periods and epoch; Origins of unicellular and multicellular organism; Major groups of plants and animals; Stages in primate evolution including Homo. | |
| 4 | Molecular Evolution: Concept of neutral evolution, origin of new genes and proteins (by gene disruption and exon shuffling); gene duplication and divergence; variation (phenotypes, chromosome structure, protein structure and nucleotide sequences); speciation, allopatry and sympatry; isolating mechanisms; convergent evolution; co-evolution; adaptive radiation. Population Genetics: Populations, Gene pool, Gene and allele frequency; Conservation of gene frequency; Hardy Weinberg Law; concepts of rate of change in gene frequency through natural selection; random genetic drift. |
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