Syllabus
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Course Code: BCH-202 Course Name: Clinical Biochemistry |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Clinical bio chemistry and quality assurance: biologicalsamples(blood,urineandcerebrospinalfluid):chemicalcomposition, collection,processing, storage and preservation;Qualitycontrol:accuracy, precision, Specificity, Sensitivity, Levy Jening’s chart. Blood: clinical significance and functions of plasma proteins (albumin, alpha 1-antitrypsin, haptoglobin, caeruloplasmin, transferrin, C-reactive protein); Disorders of hemoglobin: thalassemia, anemia (different types) and porphyrias. |
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| 2 | Clinical enzymology: Enzymes as diagnostic tool; Clinically important enzymes: alkaline phosphatase, acid phosphatase, aldolase, creatine kinase, LDH, AST, ALT, lipase, amylase and 5’-nucleotidase; isoenzymes and their diagnostic importance. Organ function tests: Assessment of liver, kidney, exocrine pancreas and G.I. tract function tests. Detoxification: Phase I and Phase II reactions. |
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| 3 | Metabolic disorders: Disordersofcarbohydratemetabolism:Diabetesmellitus, diabetic ketoacidosis,hypoglycemia,glycogenstorage disease and galactosemia; glucose tolerance test; disorders of lipid: Refsum’s disease, fatty liver and lipotropic factors, hypolipoproteinemia and hyperlipidemia.Atherosclerosis: pathogenesis and risk factors; Disorder of amino acid metabolism: Maple syrup urine disease, phenylketonuria, Alkaptonuria, cystinuria and homocystinuria; disorder of nucleic acid metabolism: Gout, Lesch-Nyhan Syndrome, Hypouricemia, Orotic Aciduria; disorders of calcium, magnesium, phosphorous, iron, copper and selenium metabolism; disorders of fat soluble (A, D, E and K) and water soluble vitamins (Thiamine, riboflavin, niacin, pyridoxine, pantothenic acid, biotin, folic acid, vitamin B12 and ascorbic acid) |
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| 4 | Hormone disturbances: disturbances related to protein hormones (anterior and posterior pituitary), steroid hormones and thyroid hormones. Electrolyte and acid base balance: disorders of electrolytes (hypernatremia, hyponatremia, hypokalemia, hyperkalemia, hyperchloremia, hypochloremia); water and acid base balance (metabolic and respiratory acidosis, metabolic and respiratory alkalosis) Neuropsychiatric disorders: Alzheimer’s & Parkinson’s disease. |
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