Syllabus
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Course Code: BCH-302 Course Name: Immunology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Introduction to immune system: Memory, specificity, diversity, innate and acquired immunity, self vs non-self discrimination, structure and functions of primary and secondary lymphoid organs. Cells involved in immune responses: Phagocytic cells and their killing mechanisms; T and B lymphocytes. Nature of antigen and antibody: Antigens vs immunogen, haptens, structure and functions of immunoglobulins; isotypic, allotypic and idiotypic variations. |
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| 2 | Humoral and cell mediated immune responses: Kinetics of primary and secondary immune responses, complement activation and its biological consequences, antigen processing and presentation, cytokines and costimulatory molecules- role in immune responses, T and B cell interactions. Major Histocompatibility Complex(MHC) genes and products: polymorphism of MHC genes, role of MHC antigens in immune responses, MHC antigens in transplantation. |
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| 3 | Generation of diversity in immune system: Clonal selection theory- concept of antigen specific receptor, organization and expression of immunoglobulin genes- generation of antibody diversity, Organization and expression of T-cell receptor genes- generation of T cell receptor diversity. Immunization: Active & passive immunization. |
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| 4 | Tolerance vs activation of immune system: Immune tolerance, immunosuppression, hypersensitivity (Types I, II, III and IV).Immune responses in diseases: Immune responses to infectious diseases: viral, bacterial and protozoal; cancer and immune system, immunodeficiency disorders and autoimmunity. |
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