Syllabus
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Course Code: BCH-201 Course Name: Metabolism -II |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Amino acid degradation: General reactions of amino acid metabolism: Transamination; Oxidative, non-oxidative deamination and decarboxylation reactions; Role of glutamine in ammonia transport; Glucose-Alanine Cycle; Urea Cycle; Metabolic breakdown of individual amino acids (both essential and non-essential) | |
| 2 | Amino acid biosynthesis: Biosynthesis of non-essential and essential amino acids; Regulation of amino acid biosynthesis; Amino acids as biosynthetic precursors of phosphocreatine, glutathione, dopamine, non-epinephrin and epinephrin, GABA, histamine, serotonin, polyamines (spermine and spermidine), and indole-3-acetic acid. Porphyrins: Structure of porphyrins; Important porphyrins occurring in nature; Biosynthesis of heme and its regulation; Degradation of heme; Regulation of heme biosynthesis; Chlorophyll biosynthesis. | |
| 3 | Nucleotide metabolism: De novo biosynthesis and regulation of purine and pyrimidine nucleotides; Salvage pathways of purines and pyrimidines; Ribonucleotide reductase and formation of deoxyribonucleotides (dNTPs) from ribonucleotides (NTPs); Catabolism of purine and pyrimidine nucleotides; Chemotherapeutic agents as inhibitors of enzymes in nucleotide biosynthetic pathways; Biosynthesis of nicotinamide coenzymes, flavin coenzymes and coenzyme A. Integration of metabolism: basic strategy of catabolic metabolism; Recurring motifs in metabolic regulation; Major metabolic pathways and control sites; Key junctions in metabolism (glucose-6-phosphate, pyruvate and acetyl CoA); Organ specific metabolic profile; Metabolic changes induced by food intake and starvation; Ethanol metabolism in the liver. | |
| 4 | Secondary plant metabolism: Primary and secondary metabolites; Isoprenoids: introduction, different classes with examples; biosynthesis of carotenoids (Limonene, Lycopene and β-Carotene); Alkaloids: definition, classification according to their heterocycles with examples; physiologically active alkaloids (used in medicine and plant chemical defense); Phenylpropanoids: Introduction; overview of products of the phenylpropanoid metabolism; Biosynthesis of lignin; Flavonoids: nature; classification of aglycons with examples; functions of flavonoids; Nature of Tannins, Cyanogenic glycosides and Glucosinolates. | |
