Syllabus
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Course Code: M-FSC 404 Course Name: Forensic Pharmachology and Drug Analysis |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | Forensic Pharmacology: Concept of pharmacology, Basic concepts of pharmacokinetics, absorption- First-pass metabolism, bioavailability, Distribution, elimination of drug- drug half life, excretion. Drug Metabolism- Phase-1 and Phase-2 (conjugation) reactions. Metabolism of ethanol, methanol, Benzodiazepines barbiturates, Amphetamines, heroin, codeine, morphine, detection of metabolits. Factors affecting the pharmacokinetics of drugs. Pharmacodynamics and pharmacogenesis. |
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| 2 | Narcotic Drugs and Psychotropic Substances: Classification of narcotic substances, NDPS act. Drugs of abuse. Opiate: extraction of alkaloids from plant materials, analysis of opium alkaloids, datura alkaloids- using spot tests, microcrystal tests, TLC, spectroscopy, GC-MS. Barbiturates and Benzodiazepines: Chemistry, types, extraction and isolation, characterization by spot tests, TLC, and IR spectrometry, HPLC – MS. |
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| 3 | Stimulants and Hallucinogen Compounds: Stimulants - Amphetamines, cocaine, nicotine, caffeine, chemistry and identification. Hallucinogens – cannabis, LSD, psilocybine and mescaline: Introduction, analysis: spot tests, TLC, and IR spectrometry, HPLC – MS, GC- MS. |
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| 4 | Extraction and Purification of Drugs/Poisons from Biological Samples:
Extraction of volatile compounds (distillation methods, head space-GC). Principle of solvent extraction method, extraction and isolation of Neutral nonvolatile compounds, acidic and basic nonvolatile compounds from viscera, blood, urine and hairs - Stas-otto method, Dovbriey Nickolls (Ammonium sulphate) method, acid digest and Valov (Tungstate) methods. Advanced Methods of Sample Purification: Solid phase extraction, Solid phase micro extraction techniques, liquid phase micro extraction method, Supercritical fluid extraction (SFE) method. |
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