Syllabus
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Course Code: M-Z 402 Course Name: Vertebrate Immunology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | 1.0 Phylogeny and Ontogeny of immune system 1.1 Innate and Acquired Immunity 1.2 Organization and structure of lymphoid organs 1.3 Cells of the immune system and their differentiation 2.0 Nature of antigens and superantigens 2.1 Antigenicity and immunogenicity 2.2 Factors influencing immunogenicity 2.3 Epitopes and haptens 3.0 Structure and Functions of Antibodies 3.1 Classes and subclasses 3.2 Gross and Fine structure 3.3 Antibody mediated effector functions 4.0 Antigen-Ab interactions: Principles and Applications 4.1 Cross Reactivity, Precipitation reactions, Agglutination reactions 4.2 Radioimmunoassay, ELISA, Immunoprecipitation, Immunofluorescence |
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| 2 | 5.0 Nature of immune response 5.1 Humoral Immune Response 5.2 Cellular Immune Response 6.0 Cytokines 6.1 Cytokine Properties 6.2 Cytokine receptors 6.3 Cytokines and Immune response 6.4 Cytokine Antagonists 6.5 Cytokine Related Diseases 7.0 Cell-mediated effector functions 7.1 Cell adhesion molecules 7.2 Effector cells and molecules 7.3 CTLs –Mechanism of action 7.4 NK cells-mechanisms of action 8.0 Hypersensitivity-Types and Mechanism. |
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| 3 | 9.0 Complement System 9.1 Components and functions of Complement system 9.2 Pathways of complement system 9.3 Regulation and biological consequences. 10.0 Major Histocompatibility Complex in mouse and HLA system in human 10.1 Class I and class II molecules 10.2 Expression and diversity 10.3 Disease susceptibility and MHC/HLA 11.0 Organization and expression of Ig genes 11.1 Multigene organization of Ig genes 11.2 DNA rearrangements and mechanisms 11.3 Generation of antibody diversity 11.4 Differential expression of Ig genes. |
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| 4 | 12.0 T-Cell Maturation, Activation and Differentiation 12.1 T-Cell Receptors- Organization and rearrangement of TCR genes, TCR-CD3 complex 12.2 T-cell maturation and thymus 12.3 T -cell activation and differentiation 12.4 Cell death and T-cell population 13.0 B-cell generation, activation and differentiation 13.1 B-cell receptors 13.2 B-cell maturation, activation and proliferation 13.3 T H-B-Cell interactions 14.0 Auto-immunity and Vaccines- Types – subunit, conjugate and recombinant vector vaccines. |
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