Syllabus
|
Course Code: M-Z 302 Course Name: Molecular Endocrinology |
||
| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
|---|---|---|
| 1 | 1. Basic concept of endocrinology, its scope and role in molecular biology. 2. Chemical nature of hormones; 2.1 Amino-acid derived hormones 2.2 Peptide hormones 2.3 Glyco-protein hormones, 2.4 Steroid hormones and 2.5 Prostaglandin 3. Biosynthesis of peptide hormones, transcriptional and post-transcriptional modifications 4. Biosynthesis and secretion of thyroid hormones. Thyroid hormone disorders. |
|
| 2 | 5. Prostaglandin structure, type, synthesis and biological activities. 6. Mechanism of action of peptide hormones; concept of second messengers, cAMP, cGMP, Ca++, IP3, DAG, NO, signal transduction mechanisms. 7. Mechanism of action of steroid hormones; Cross talk concept, Heat shock proteins. |
|
| 3 | 8. Hormonal regulation of Metabolism: 8.1 Role of Insulin & Glucagon in regulation of Carbohydrate metabolism 8.2 Metabolic regulatory hormones in Lipid & Protein metabolism 9. Gastrointestinal hormones and their role in regulation of metabolic activity. 10. Endocrine regulation of calcium and phosphate homeostasis in mammals. |
|
| 4 | 11. Genetic basis of hormonal disorders. 11.1 General principle and classification of hormonal disorders 11.2 Genetic basis of growth hormone disorder 11.3 Genetic basis of PCOS 12. Sequence-specific DNA binding receptor proteins 12.1 Nuclear receptor proteins 12.2 Cytosolic receptor proteins 12.3 Cell surface receptor proteins 12.4 Their role in gene transcription, cell differentiation and cell proliferation. 13.0 Regulatory substances –Eicosanoids, Growth factors, Thymus gland & Kinins. |
|
