Syllabus
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Course Code: M-Z 101 Course Name: Cell Biology |
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| MODULE NO / UNIT | COURSE SYLLABUS CONTENTS OF MODULE | NOTES |
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| 1 | 1. Biomembranes 1.1 Molecular composition and arrangement, functional consequences 1.2 Cellular Transport – Recapitulation of the plasma membrane; diffusion, active transport and pumps, uniports, symports and antiports. 1.3 Donnan equilibrium; ion movements and cell function: acidification of cell organelles 1.4 Maintenance of cellular pH; cell excitation; bulk transport; Receptor mediated endocytosis 1.5 Transepithelial transport 2 Cytoskeleton and cell movement 2.1 Introduction to cytoskeleton and its role 2.2 Molecular structure of Actin, myosin and their organisation 2.3 Structure and dynamic organizations of microtubules and microfilaments 2.4 Microtubule motors and movement 2.5 Intermediate filaments 2.6 Role of Centrioles and basal bodies 2.7 Structure and functions of Cilia and flagella |
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| 2 | The Extra Cellular Matrix and Cell interactions 3.1 Cell walls 3.2 The ECM and cell-matrix interactions 3.3 Cell-cell interactions: adhesion junctions, tight junctions, gap junctions, plasmodesmata 3.4 Ca++ dependent and Ca++ independent Homophilic cell-cell adhesion 4 Cell matrix adhesion 4.1 Integrins 4.2 Collagen 4.3 Non-collagen components 4.4 Auxin and cell expansion 4.5 Cellulose fibril synthesis and orientation 5 Protein sorting and transport 5.1 Protein uptake into the ER 5.2 Membrane proteins and Golgi sorting 5.3 Mechanism of vesicular transport 5.4 Lysosomes 5.5 Molecular mechanism of secretory pathway |
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| 3 | 6 Cell cycle 6.1 Eukaryotic cell cycle 6.2 Regulators of cell cycle progression 6.3 Role of Meiosis in Genetic Variation 7 Cell – Cell signaling 7.1 Signaling molecules and their receptors 7.2 Pathways of intracellular signal transduction 8 Biology of Cancer 8.1 The development and causes of cancer 8.2 Oncogenes 8.3 Tumor suppressor genes 8.4 Molecular approaches to cancer treatment |
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| 4 | 9 Genome organization 9.1 Chromosomal organization of genes 9.2 Transposons in prokaryotes and eukaryotes 9.3 Morphological and functional elements of eukaryotic chromosomes 10 Cell Death 10.1 Necrosis and Programmed cell death 10.2 Molecular Mechanism 10.3 Applications and Significance 11 Biology of Ageing 11.1 Morphological, Physiological and Functional changes during Ageing 11.2 Telomeres and Ageing 11.3 Theories of Ageing |
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